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Nø Cosmetics Hyperdration 4D Hyaluron SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
The big brother of glycerin. It's also a natural moisturizing factor that reduces water evaporation from the upper layer of the skin and helps to keep water in the skin so that it stays nicely hydrated.
Compared to glycerin, it has a larger molecular structure (kind of a double glycerin). Thanks to this, it penetrates slower into the skin but gives longer lasting moisture and less sticky, better skin-feel.
Ectoin is a surprisingly well-researched, multi-functional active that can do from pollution & light protection to skin hydration, soothing, and barrier repair, several things to your skin.
It is an extremolyte, a small stress-protection molecule that protects microorganisms living under extreme conditions such as salt lakes, hot springs, arctic ice, the deep sea, or deserts. It was discovered in 1985 in a microorganism living in a salt lake in the Egyptian desert.
The key skill of Ectoin is protection that applies also to the skin. Its main mode of action is binding water molecules (aka kosmotropic) and creating hydro complexes. These complexes then surround important biomolecules (e.g. cells, proteins, enzymes) and form a stabilizing hydration shell around them.
This protection mechanism means good things when it comes to our skin: Ectoin has antioxidant, anti-inflammatory, pollution& light protecting, skin hydrating, barrier repairing as well as anti-aging properties.
A placebo-controlled 10-person study examined a four-week treatment with 0.5% Ectoin in the crow's feet area and found a significant anti-wrinkle effect (-19% mean wrinkle depth) in 100% of the participants. Another double-blind, placebo-controlled clinical study with 24 participants used a 2% Ectoin cream twice a day for 4 weeks and found an improvement in all of the measured parameters, such as wrinkle volume, skin scaling, roughness, and elasticity.
Another remarkable property of Ectoin is protecting the epidermal immune cells called Langerhans cells from UV damage. 0.3% and 0.5% Ectoin cream was used twice a day for 14 days on the forearm and then irradiated with 1.5 MED UV (one and a half times the UV dose that causes detectable redness). While the untreated, UV-stressed area showed a 40% decrease in viable Langerhans cells, 0.5% Ectoin showed 100% protection (and 0.3% showed ~95% protection).
The soothing efficacy is also backed up by multiple in-vivo studies. A 20-person study compared 1% Ectoin cream to 0.25% hydrocortisone treatment on surfactant irritated skin and found similar effectiveness in reducing skin redness. Another study with 23 females with sensitive skin found that a 1% Ectoin cream helped to tolerate a 0.5% or 1% retinol treatment much better.
A tiny, 5-person study examined the long-term (7 days) skin hydration effect of 1% Ectoin. During the study, hydration levels increased up to 200% compared to placebo, and even 7 days after stopping the treatment hydration status was largely preserved. Higher concentration (5-7%) Ectoin treatments are also used as OTC medical products for the treatment of eczema or atopic skin.
The anti-pollution magic properties are also well-established and Ectoin is currently the only anti-pollution active ingredient approved for use in medical products (e.g. inhalation solutions) in Europe. Clinical studies showed a reduction of inflammations in human lungs of patients with COPD (a pulmonary disease) and pollution-induced asthma. But coming back to the skin, Ectoin protects both from PMs (Particulate Matters, including ultrafine) as well as PAHs (Polycyclic Aromatic Hydrocarbons) and heavy metals.
If that weren't enough, Ectoin is also shown to protect the skin from blue and visible light, and pigmentation resulting from environmental stress (think UV, pollution, oxidative stress).
All in all, we think Ectoin is one of those under-the-radar actives that deserves more hype than it is currently getting. As an amazing all-around skin protectant, it is a useful addition to any skincare routine.
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
Sodium Acetylated Hyaluronate is a variation of current IT moisturizer, Hyaluronic acid, where some water-loving -OH groups are replaced by amphipathic (partly water-loving and partly water-hating) acetyl groups. The modified molecule is claimed to have even better moisture retention ability than normal HA and better affinity to the skin surface.
The better affinity comes from the acetyl groups that act as tiny "anchors" to attach the HA molecule to the skin. Staying on top of the skin better and longer means longer-lasting surface hydration and improved elasticity. It is also less sticky and more cosmetically elegant than normal HA, so no wonder the nickname of this molecule is super hyaluronic acid.
It's a super small, chemically chopped up version of sodium hyaluronate. Its trade name is miniHA, and its molecular weight is 10 kDa. This counts as really tiny given that "normal" HA has a molecular weight of 0.5-2 million Da.
To be honest, low molecular weight (LMW), and especially this ultra-low molecular weight HA is a controversial ingredient. On the upside, it can penetrate the skin better (though 10kDa still counts as big!) and might be able to moisturize the deeper layers of the skin where normal HA cannot get. Also, according to the manufacturer of miniHA, it has better antioxidant activity than a 1.6MDa version HA and it also has better sun protection and after-sun repair abilities than the higher MW versions. It also works in synergy with higher molecular weight versions, and the combination of 0.1% 1.45MDa-HA + 0.1% 380 kDa-HA + 0.1% miniHA hydrated the skin significantly better than 0.3% 1.45MDa-HA alone.
On the downside, the biological role of LMW-HA in the skin is being a pro-inflammatory signaling agent and there is a study by another manufacturer called Evonik showing that HA versions with smaller than 50kDa molecular weight might be pro-inflammatory when put on the skin. Granted, the study was only done on reconstituted human epidermis, so it might or might not be like this on real human skin.
If you wanna get confused and read much more about hyaluronic acid and what the different molecular weight versions might or might not do, click here and read our excruciatingly long description.
A type of sugar molecule, that has water-binding properties and helps to keep your skin hydrated.
A glycerin-derived gentle cleansing agent that is described as being skin and eye-friendly, and not leaving the skin dry or tight. It's also used as a co-emulsifier or solubilizer that helps to blend small amounts of oily things into water-based products.
A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.
We don't have description for this ingredient yet.
A natural polymer (big molecules from repeated subunits) that is harvested from the Acacia tree in the sub-Saharan region in Africa. It's a great thickening and binding agent. Often coupled with xanthan gum, as it helps to reduce its unpleasant stickiness.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4).
But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.
BTW, it’s also a food preservative and even has an E number, E202.
A helper ingredient that helps to make the products stay nice longer, aka preservative. It works mainly against fungi.
It’s pH dependent and works best at acidic pH levels (3-5). It’s not strong enough to be used in itself so it’s always combined with something else, often with potassium sorbate.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA.
So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh.
There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin.
But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation.
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| what‑it‑does | solvent |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| what‑it‑does | antioxidant | soothing | moisturizer/humectant |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | surfactant/cleansing | viscosity controlling |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | emulsifying |
| what‑it‑does | surfactant/cleansing | emulsifying |
| what‑it‑does | emollient | viscosity controlling |
| irritancy, com. | 2, 2 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | buffering |