Vitapair C Pdrn Radiance Serum
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Nature Republic Vitapair C Pdrn Radiance SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
We don't have description for this ingredient yet.
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
We don't have description for this ingredient yet.
A nice odorless liquid used mainly as a superior solubilizer and efficacy booster for cosmetic active ingredients such as skincare bigshot vitamin C, self-tanning active DHA or the anti-acne gold standard, benzoyl peroxide.
Other than that it can also be used in hair care products where it gives a longer-lasting and more uniform coloring. According to a manufacturer, it might even prevent the formation of split ends.
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.
It's a little helper ingredient that helps to set the pH of the products to be right. It has an alkaline pH and can neutralize acidic ingredients.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
A versatile polymer that helps to thicken up products and can also act as an emulsifier, enabling gel-cream-like textures. It works over a wide pH range and is electrolyte tolerant.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
An optical isomer of naturally occurring arbutin (or beta-arbutin). Just like its sibling, alpha-arbutin is also a skin-brightening, depigmenting agent.
Researching the difference between the two kinds of arbutin, you can read in multiple places on the internet that alpha-arbutin is stronger in effect. Unfortunately, it's never backed up with a credible source. :( Our own research resulted in conflicting results: a study from 1995 found that alpha-arbutin is 10x as effective on mouse melanoma as beta-arbutin. On the other hand, a more recent study from 2015 found that beta-arbutin is more effective both on mouse melanoma cells and on human melanoma cells (btw, kojic acid was the most effective on human melanoma cells).
None of the studies we could find is in-vivo (made on real people) anyways, so who knows. We think you cannot go wrong with trying both beta- and alpha-arbutin and see if one works better for you than the other.
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:
- It can help with wound healing
- It’s a good anti-inflammatory agent
- It might even help with skin’s own collagen production and improve skin firmness and elasticity
- It helps with barrier repair and protection
- It might be even useful for the hair helping with hair thickness and hair growth
Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!).
If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.
Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
The salt form of one of the main anti-inflammatory ingredients in the licorice plant, monoammonium glycyrrhizinate. It’s a yellowish powder with a nice sweet smell.
It’s used mainly for its soothing and anti-inflammatory properties, but according to manufacturer info, it’s also sebum regulating so it's a perfect ingredient for problem skin products.
Read more about licorice and why it's a skincare superstar here.
It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
If life gives the cosmetic industry lemon, it makes lemon fruit extract. As to why, we can write here extremely similar things to our shiny description of orange fruit extract. Being both of them citruses, they contain very similar active compounds with very similar (potential) effects on the skin.
Just like orange fruit, lemon fruit also contains citric acid so it is commonly used as a natural, mild exfoliating agent. If this is the case, it is usually combined with other AHA containing fruit extracts such as bilberry, sugar cane, orange, and sugar maple in a super popular ingredient mix trade named ACB Fruit Mix.
But, citrus fruits are chemically complex mixtures with a bunch of other active components such as vitamin C, flavonoids, phenolics, carbohydrates and essential oil (this latter one coming from the rind of the fruit, but still present in some amount in the fruit extract). These have the potential to give lemon extract antioxidant, antibacterial, anti-dandruff, venotonic and moisturizing properties, but the essential oil also brings some questionable compounds such as fragrance allergen limonene or phototoxic compound bergaptene. If your skin is sensitive, be careful with citrus extracts.
We don't have description for this ingredient yet.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
Turmeric is the yellow spice you probably know from curry and Indian food. It's also a traditional herbal medicine used in Ayurveda for its bunch of anti-something magic abilities including being anti-inflammatory, antimicrobial, antioxidant and anticarcinogenic.
As for turmeric and skincare, we have good news: studies show that the root extract and its main biologically active component, curcumin can do multiple good things for the skin. Thanks to its anti-inflammatory and antimicrobial activity, it shows some promise for acne-prone skin and a small study from 2013 showed that it might be able to regulate sebum production.
It's also a potent antioxidant and skin-brightening agent so it often shows up in anti-aging and/or radiance-boosting products.
We don't have description for this ingredient yet.
Beta-Glucan is a nice big molecule composed of many smaller sugar molecules (called polysaccharide). It’s in the cell walls of yeast, some mushrooms, seaweeds, and cereals.
It’s a real goodie no matter if you eat it or put it on your face. Eating it is anti-diabetic, anti-cancer, and even lowers blood cholesterol.
Putting it on your face also does a bunch of good things: it‘s shown to have intensive skin repairing & wound healing properties, it’s a mild antioxidant, a great skin soother, and moisturizer, and it even shows promising anti-aging benefits.
The manufacturer of the ingredient did a published study with 27 people and examined the effect of 0.1% beta-glucan. They found that despite the large molecular size the smaller factions of beta-glucan penetrate into the skin, even into the dermis (the middle layer of the skin where wrinkles form). After 8 weeks there was a significant reduction of wrinkle depth and height and skin roughness has also improved greatly.
Bottom line: Beta-glucan is a great ingredient, especially for sensitive or damaged skin. It soothes, moisturizes, and has some anti-aging magic properties.
It's a special "cross-linked" from of IT-moisturizer, hyaluronic acid (HA). Cross-linked means that "normal" HA pieces (1-2 million Da molecular weight) are chemically bound togeather to create a big, "infinite" mesh.
The special HA mesh has a remarkable water-binding capacity, 5 times more than the already crazy water-binding capacity of "normal" HA. This water filled crosslinked HA gel forms a smooth film on the skin and continuously delivers the bound water, so it gives long-term moisturizing benefits.
Btw, crosslinking HA was developed for dermal fillers (as crosslinking helps their longevity), and this guy is the topical version of FDA approved dermal filler called Hylan B gel. Smearing crosslinked version all over ourselves is a newish thing, and incoming evidence so far suggests that it's a great idea, even better than normal HA.
A very recent, 2016 research article compared the topical moisturizing effect of crosslinked HA (not Hylan B gel specifically, but something called Resilient HA or RHA), HMW-HA and LMW-HA and found that "TEWL (that is trans-epidermal water loss, the water that evaporates from the skin) was reduced by 27.8% with RHA, and by 15.6% with HMW HA, but increased by 55.5% with LMW HA." (You can read much more about HMW and LMW HA here in the geeky details section.)
All in all, we think Sodium Hyaluronate Crosspolymer is an awesome version of HA, probably superior to traditional versions, so be happy to spot it on the ingredient list.
- Works best between a concentration of 5-20%
- Boosts the skin’s own collagen production
- Fades pigmentation and brown spots
- If used under sunscreen it boosts its UV protection
- Extremely unstable and oxidizes very easily in presence of light or air
- Stable in solutions with water only if pH is less than 3.5 or in waterless formulations
- Vit E + C work in synergy and provide superb photoprotection
- Ferulic acid doubles the photoprotection effect of Vit C+E and helps to stabilize Vit C
- Potent Vit. C serums might cause a slight tingling on sensitive skin
A form of skincare superstar, vitamin C. If you do not know why vitamin C is such a big deal in skincare, we have a really detailed, geeky description that's good to read. :)
So now you know that because pure vitamin C is such a diva (very unstable and hard to formulate) the cosmetic industry is trying to come up with some derivatives that have the badass anti-aging properties of vitamin C (antioxidant protection + collagen boosting + fading hyperpigmentation) but without the disadvantages. This is a hard task, and there is not yet a derivative that is really proven to be better in every aspect, but Ascorbyl Glucoside is one of the best options when it comes to vitamin C derivatives. Let's see why:
First, it's really stable and easy to formulate, so the problems that come with pure vitamin C are solved here.
Second, in vitro (meaning made in the lab, not on real humans) studies show that ascorbyl glucoside can penetrate the skin. This is kind of important for an anti-aging ingredient to do the job, so this is good news, though in-vivo (made on real humans) studies are still needed.
Third, in-vitro studies show that after ascorbyl glucoside is absorbed into the skin it is converted to pure vitamin C (though the rate of conversion is still a question mark). It also shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does.
Bottom line: ascorbyl glucoside is one of the best and most promising vitamin C derivatives that shows similar benefits to that of pure vitamin C, but it's less proven (in vivo vs. in vitro studies) and the extent of the benefits are also not the same.
Centella Asiatica - or sometimes also called Gotu Kola or Cica - has been used in folk medicine for hundreds of years. It’s traditionally used to improve small wounds, burns and scratches and it’s also a well known anti-inflammatory agent for eczema.
Recently science has taken an interest in Gotu Kola as well and it turns out it really has many active compounds with several benefits. Just for hard-core geeks, the main biologically active compounds are pentacyclic triterpenoid saponins called asiaticoside, madecassoside, asiatic and madecassic acid (also called centellosides).
One of the biological activities of the centellosides is to be able to stimulate GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells), and especially hyaluronic acid synthesis in our skin. This is probably one of the reasons why Centella Asiatica Extract has nice skin moisturizing properties that was confirmed by a 25 people, four weeks study along with Centella's anti-inflammatory effects.
Madecassoside can also help in burn wound healing through increasing antioxidant activity and enhancing collagen synthesis. Asiaticoside was shown to increase antioxidant levels on rats skin when applied at 0.2%.
Centella Asiatica also often shows up in products that try to treat cellulite or striae. Of course, it cannot make a miracle but it might have some effect via regulating microcirculation and normalizing the metabolism in the cells of connective tissues.
Bottom line: Gotu Kola is a great plant ingredient with proven wound healing, anti-inflammatory, and antioxidant properties. Nice to spot on any ingredient list.
We don't have description for this ingredient yet.
- Primary fat-soluble antioxidant in our skin
- Significant photoprotection against UVB rays
- Vit C + Vit E work in synergy and provide great photoprotection
- Has emollient properties
- Easy to formulate, stable and relatively inexpensive
Though its name does not reveal it, Carnosine is a peptide, a small, two amino acid (β-Ala-His) one. It is naturally present in high concentrations in muscle and brain tissues, but the one used in cosmetic products is biomimetic, meaning that it is synthetically produced in a lab to copy the natural thing.
A 2017 review paper on topical peptides writes about Carnosine that it is a "well-documented aqueous antioxidant with wound healing activity".
Other than that we can write about manufacturer-done in-vitro (in the lab, not on real people) studies that show Carnosine to have anti-glycation properties. Glycation is the not-so-nice process that happens when we bombard our body with too much sugar that results in damaged body proteins and eventually in more wrinkles.
Also, a manufacturer done in vitro study shows that carnosine might have collagen-boosing magic power. However, the 2017 research paper also mentions that even though Carnosine is a small molecule, it is water soluble and does not penetrate the skin past the top layers so we have some doubt if the collagen-boosting works in real life. We could find one anti-aging study made on real people that mentions Carnosine, but it was combined with a bunch of other anti-aging actives so it is pretty much impossible to know what Carnosine did or did not.
One last thing to mention is that there is also a manufacturer done clinical study (done on real people) that shows carnosine being effective against the damages caused by infrared (IR) radiation. (source)
Ferulic Acid (FA) is a goodie that can be found naturally in plant cell walls. There is a lot of it especially in the bran of grasses such as rice, wheat and oats.
FA - whose main job is to be an antioxidant - owes its fame to a 2005 research that discovered that adding in 0.5% FA to a 15% Vitamin C + 1% Vitamin E solution not only stabilizes the highly unstable, divaish Vit C, but it also doubles the photoprotection abilities of the formula.
Couple of other studies show that FA just by itself is also a nice addition to cosmetic formulations: it can penetrate the skin (which is kind of important to do the job) and it has protecting properties against UV caused skin damage.
So if you spot it on the ingredient list be happy about it. :)
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| what‑it‑does | solvent |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | antioxidant | moisturizer/humectant |
| what‑it‑does | solvent | moisturizer/humectant | perfuming |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | soothing | antioxidant | moisturizer/humectant |
| what‑it‑does | emulsifying | surfactant/cleansing |
| irritancy, com. | 0, 0 |
| what‑it‑does | viscosity controlling |
| irritancy, com. | 0, 1 |
| what‑it‑does | buffering |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | preservative |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | perfuming |
| what‑it‑does | viscosity controlling |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | chelating |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | antioxidant | soothing | skin brightening | perfuming |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | antioxidant | moisturizer/humectant |
| what‑it‑does | antioxidant | skin brightening | buffering |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | soothing | antioxidant | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | antioxidant |
| irritancy, com. | 0-3, 0-3 |
| what‑it‑does | antioxidant | cell-communicating ingredient |
| what‑it‑does | antioxidant | antimicrobial/antibacterial |